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This medication has been explored as a therapeutic option for PD due to its inhibitory effects both on the release of transforming growth factor (TGF) from fibroblasts and TGF-receptors

CA19-9 is the most commonly used biomarker, and a glycoprotein, despite its low specificity and sensitivity, especially in early-stage disease and in patients who lack the Lewis antigen (~510% of the population), which is required for CA19-9 expression

Excessive accumulation of ROS leads to lipid peroxidation and, consequently, membrane damage, protein degradation, enzyme inactivation, and DNA damage (Hernndez et al

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